The MSTN Polyclonal Antibody (CAB6913) is a valuable tool for research involving myostatin (MSTN), a key regulator of muscle growth and development. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the MSTN protein, researchers can detect and analyze its expression levels in various cell types, providing important insights into muscle biology and potential therapeutic targets.Myostatin, also known as growth differentiation factor 8 (GDF-8), plays a crucial role in controlling muscle mass by inhibiting muscle cell growth and differentiation.
Dysregulation of MSTN has been implicated in muscle wasting conditions such as muscular dystrophy and sarcopenia, making it a promising target for drug development and treatment strategies aimed at promoting muscle growth and regeneration.The MSTN Polyclonal Antibody is a valuable tool for researchers studying muscle biology, regenerative medicine, and therapeutic interventions for muscle-related disorders. Its specificity and sensitivity make it a reliable choice for detecting and quantifying MSTN expression levels, advancing our understanding of muscle physiology and potential treatment options for muscle-related conditions.
Product Name:
MSTN Rabbit Polyclonal Antibody
SKU:
CAB6913
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 267-375 of human GDF-8/Myostatin (NP_005250.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.
Purification Method:
Affinity purification
Gene ID:
2660
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using GDF-8/Myostatin Rabbit pAb (CAB6913) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
