The MSRB1 Polyclonal Antibody (CAB6737) is a valuable tool for researchers studying the role of MSRB1, a mitochondrial protein involved in antioxidant defense and redox regulation. This antibody, generated in rabbits, shows high specificity for human samples and is suitable for use in Western blot applications. By binding to the MSRB1 protein, this antibody allows for the detection and analysis of MSRB1 expression in various cell types, making it ideal for investigations in the fields of oxidative stress, mitochondrial function, and aging research.MSRB1, also known as methionine sulfoxide reductase B1, plays a crucial role in maintaining cellular redox balance by reducing oxidized methionine residues in proteins.
Dysregulation of MSRB1 has been associated with various diseases, including neurodegenerative disorders and cancer. By studying the function of MSRB1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention.Overall, the MSRB1 Polyclonal Antibody (CAB6737) offers researchers a reliable tool for investigating the biological functions of MSRB1 and its implications in disease pathology. Its high specificity and validated performance in Western blot applications make it a valuable asset for those interested in exploring the role of MSRB1 in health and disease.
Product Name:
MSRB1 Rabbit Polyclonal Antibody
SKU:
CAB6737
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human MSRB1 (NP_057416.1).
The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19.
Purification Method:
Affinity purification
Gene ID:
51734
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MSRB1 Rabbit pAb (CAB6737) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
