MSRB1 Rabbit Polyclonal Antibody (CAB6737)
- SKU:
- CAB6737
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | MSRB1 Rabbit Polyclonal Antibody |
SKU: | CAB6737 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human MSRB1 (NP_057416.1). |
Sequence: | MSFC SFFG GEVF QNHF EPGV YVCA KCGY ELFS SRSK YAHS SPWP AFTE TIHA DSVA KRPE HNRS EALK VSCG KCGN GLGH EFLN DGPK PGQS RF |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:500 IF/ICC,1:50 - 1:100 |
Synonyms: | SELR; SELX; SepR; SEPX1; HSPC270; SELENOR; SELENOX; MSRB1 |
Positive Sample: | HL-60,SW620,Mouse brain,Mouse kidney,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, cytoskeleton. |
Calculated MW: | 13kDa |
Observed MW: | 13kDa |
The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19.
Purification Method: | Affinity purification |
Gene ID: | 51734 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |