The MSR1 Polyclonal Antibody (CAB14187) is a valuable tool for research involving the macrophage scavenger receptor 1 (MSR1), a key player in the innate immune response system. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.MSR1 plays a crucial role in the clearance of pathogens, apoptotic cells, and debris, making it essential for maintaining tissue homeostasis and immune response regulation. Changes in MSR1 expression or function have been linked to various diseases, including atherosclerosis, Alzheimer's disease, and cancer.
By targeting the MSR1 protein, this polyclonal antibody enables researchers to detect and analyze MSR1 in different cell types, providing valuable insights into its role in immunity and disease pathogenesis. Its versatility and reliability make it an ideal tool for studies in immunology, inflammation, and infectious diseases. Explore the potential of MSR1 in various research applications with the MSR1 Polyclonal Antibody (CAB14187).
Product Name:
MSR1 Rabbit Polyclonal Antibody
SKU:
CAB14187
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 192-451 of human MSR1 (NP_619729.1).
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Purification Method:
Affinity purification
Gene ID:
4481
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MSR1 antibody (CAB14187) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
