MSR1 Rabbit Polyclonal Antibody (CAB14187)
- SKU:
- CAB14187
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | MSR1 Rabbit Polyclonal Antibody |
SKU: | CAB14187 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 192-451 of human MSR1 (NP_619729.1). |
Sequence: | LNIE NLNG KIQE NTFK QQEE ISKL EERV YNVS AEIM AMKE EQVH LEQE IKGE VKVL NNIT NDLR LKDW EHSQ TLRN ITLI QGPP GPPG EKGD RGPT GESG PRGF PGPI GPPG LKGD RGAI GFPG SRGL PGYA GRPG NSGP KGQK GEKG SGNT LTPF TKVR LVGG SGPH EGRV EILH SGQW GTIC DDRW EVRV GQVV CRSL GYPG VQAV HKAA HFGQ GTGP IWLN EVFC FGRE SSIE ECKI RQWG TRAC SHSE DAGV TCTL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII; MSR1 |
Positive Sample: | LO2,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type II membrane protein. |
Calculated MW: | 50kDa |
Observed MW: | 60-90kDa |
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Purification Method: | Affinity purification |
Gene ID: | 4481 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |