The MSMO1 Polyclonal Antibody (PAC019616) is a valuable tool for researchers studying MSMO1, a key enzyme involved in cholesterol biosynthesis. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MSMO1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential reagent for studies in lipid metabolism and related diseases.MSMO1 is an important enzyme in the mevalonate pathway, responsible for converting mevalonate into isopentenyl pyrophosphate. This process is crucial for the production of cholesterol, steroid hormones, and other essential molecules in the body.
Dysregulation of MSMO1 activity has been linked to various diseases, including metabolic disorders and cancer, making it a promising target for therapeutic interventions.By understanding the role of MSMO1 in cholesterol synthesis and related pathways, researchers can gain insights into the development of new treatments for cardiovascular diseases, hypercholesterolemia, and other conditions involving lipid metabolism. The MSMO1 Polyclonal Antibody is a reliable tool for investigating the function and regulation of this enzyme, advancing our knowledge of cholesterol homeostasis and its implications for human health.
Antibody Name:
MSMO1 Antibody (PACO19616)
Antibody SKU:
PACO19616
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MSMO1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19616(MSMO1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19616(MSMO1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms:
methylsterol monooxygenase 1
UniProt Protein Function:
SC4MOL: Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Protein type: EC 1.14.13.72; Oxidoreductase; Membrane protein, multi-pass; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integralChromosomal Location of Human Ortholog: 4q32-q34Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; plasma membraneMolecular Function: C-4 methylsterol oxidase activityBiological Process: cholesterol biosynthetic process; fatty acid metabolic process; steroid metabolic process
UniProt Protein Details:
NCBI Summary:
Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
