The MSLN Polyclonal Antibody (CAB14099) offered by AssayGenie is a valuable tool for researchers studying the Mesothelin (MSLN) protein, which is known to play a role in cancer progression and metastasis. This antibody, raised in rabbits, is highly specific to human MSLN samples and is validated for use in applications such as Western blotting.Mesothelin is a cell surface protein that is overexpressed in various types of cancer, including mesothelioma, ovarian cancer, and pancreatic cancer. By targeting MSLN, researchers can better understand the mechanisms behind tumor growth and potentially develop new therapies targeting this protein.
The MSLN Polyclonal Antibody enables the detection and analysis of MSLN in a variety of cell types, making it a versatile tool for cancer research. Its high specificity and sensitivity make it a reliable choice for studying the role of MSLN in cancer development and progression. By gaining a deeper understanding of MSLN function, researchers can uncover new insights into cancer biology and potentially identify novel treatment strategies.
Product Name:
MSLN Rabbit Polyclonal Antibody
SKU:
CAB14099
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 296-606 of human Mesothelin (NP_037536.2).
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
10232
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from OVCAR3 cells, using Mesothelin Rabbit pAb (CAB14099) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
