The MSL3 Polyclonal Antibody (PACO10624) is a valuable tool for researchers studying the MSL3 protein, a key component of the MSL (male-specific lethal) complex involved in dosage compensation in Drosophila. This antibody, produced in rabbits, has high specificity and sensitivity for detecting MSL3 in various samples and is validated for use in Western blot applications.MSL3 plays a crucial role in regulating gene expression by participating in chromatin remodeling and epigenetic modifications. Its function in dosage compensation ensures equal gene expression between males and females by increasing transcription of genes on the single X chromosome in males.
Research on MSL3 is essential for understanding chromatin structure and gene regulation mechanisms in development and disease.By targeting MSL3, researchers can gain insights into how chromatin modifications impact gene expression and potentially uncover new therapeutic targets for diseases related to epigenetic dysregulation. The MSL3 Polyclonal Antibody is a valuable tool for investigating the intricate roles of MSL3 in chromatin biology and gene regulation processes.
MSL3L1: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factorChromosomal Location of Human Ortholog: Xp22.3Cellular Component: NuA4 histone acetyltransferase complex; nucleoplasmMolecular Function: DNA binding; methylated histone residue bindingBiological Process: chromatin remodeling; chromatin silencing; histone deacetylation
UniProt Protein Details:
NCBI Summary:
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
