The MSI1 Polyclonal Antibody (PAC020823) is a valuable tool for researchers studying the MSI1 protein, a member of the Musashi family of RNA-binding proteins. This antibody, produced in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.MSI1 is known for its role in regulating RNA metabolism, particularly in stem cells and cancer cells. It is involved in the maintenance of stem cell properties and the promotion of tumor growth through the regulation of gene expression. The MSI1 antibody binds specifically to the MSI1 protein, allowing for its detection and analysis in various cell types.
Research into MSI1 and its functions is crucial for understanding its role in stem cell biology, cancer progression, and other diseases. Targeting MSI1 may lead to the development of novel therapeutic strategies for cancer treatment and regenerative medicine. The MSI1 antibody is an essential tool for studying the mechanisms underlying MSI1-mediated processes and their implications for various pathological conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20823(MSI1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 12%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20823(MSI1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20823(MSI1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.
Synonyms:
musashi RNA-binding protein 1
UniProt Protein Function:
Musashi-1: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. Belongs to the Musashi family.
UniProt Protein Details:
Protein type:RNA-binding
Chromosomal Location of Human Ortholog: 12q24
Molecular Function:RNA binding
Biological Process: nervous system development
NCBI Summary:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
