MSH6 Rabbit Polyclonal Antibody (CAB3177)
- SKU:
- CAB3177
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MSH6 Rabbit Polyclonal Antibody |
SKU: | CAB3177 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1061-1360 of human MSH6 (P52701). |
Sequence: | LCLA NYSR GGDG PMCR PVIL LPED TPPF LELK GSRH PCIT KTFF GDDF IPND ILIG CEEE EQEN GKAY CVLV TGPN MGGK STLM RQAG LLAV MAQM GCYV PAEV CRLT PIDR VFTR LGAS DRIM SGES TFFV ELSE TASI LMHA TAHS LVLV DELG RGTA TFDG TAIA NAVV KELA ETIK CRTL FSTH YHSL VEDY SQNV AVRL GHMA CMVE NECE DPSQ ETIT FLYK FIKG ACPK SYGF NAAR LANL PEEV IQKG HRKA REFE KMNQ SLRL FREV CLAS ERST VDAE AVHK LLTL IKEL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:100 |
Synonyms: | GTBP; HSAP; p160; GTMBP; MSH-6; HNPCC5; LYNCH5; MMRCS3; MSH6 |
Positive Sample: | HeLa,A-549,MCF7,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus. |
Calculated MW: | 153kDa |
Observed MW: | 200kDa |
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Purification Method: | Affinity purification |
Gene ID: | 2956 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |