MSH6 Monoclonal Antibody
- SKU:
- CAB22652
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IHC
- IF
Description
MSH6 Monoclonal Antibody (CAB22652)
The MSH6 Monoclonal Antibody offered by Assay Genie is essential for research involving the mismatch repair protein MSH6. This antibody, raised in mice, is highly specific for human samples and is validated for use in various applications, including Western blot, immunohistochemistry, and flow cytometry.MSH6 is a key protein involved in DNA mismatch repair, playing a critical role in maintaining genomic stability and preventing mutations that can lead to cancer development. Studying the function and expression of MSH6 is crucial for understanding the mechanisms of DNA repair and identifying potential therapeutic targets for cancer treatment.
The MSH6 Monoclonal Antibody specifically binds to the MSH6 protein, allowing for accurate detection and analysis in a variety of cell types and tissues. Its high specificity and sensitivity make it a valuable tool for researchers in the fields of oncology, genetics, and molecular biology.Overall, the MSH6 Monoclonal Antibody from Assay Genie is a reliable reagent for investigating the role of MSH6 in DNA repair pathways and cancer development, providing valuable insights that can advance our understanding of disease mechanisms and potentially lead to the development of novel treatment strategies.
| Product Name: | MSH6 Monoclonal Antibody |
| Product Code: | CAB22652 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57727 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:100-1:500, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, C2C12, NIH/3T3, Rat testis |
| Cellular Location: | Chromosome, Nucleus |
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MSH6 (NP_000170.1). |
| Sequence: | MSRQS TLYSF FPKSP ALSDA NKASA RASRE GGRAA AAPGA SPSPG GDAAW SEAGP GPRPL ARSAS PPKAK NLNGG LRRSV APAAP TSCDF SPGDL VWAKM |
| Synonyms: | GTBP, HSAP, p160, GTMBP, MSH-6, HNPCC5, LYNCH5, MMRCS3 |
| Calculated MW: | 153kDa |
| Observed MW: | 180kDa |
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