The MSH4 Polyclonal Antibody (CAB8556) is a valuable tool for researchers studying MSH4, a key protein involved in DNA repair and genomic stability. This antibody, produced in rabbits, has high specificity and sensitivity for detecting MSH4 in human samples, making it ideal for use in Western blot applications.MSH4 is a member of the MutS homolog family and plays a crucial role in the process of meiotic recombination, ensuring the accurate segregation of chromosomes during cell division. Dysregulation of MSH4 has been implicated in genetic disorders and tumorigenesis, making it a promising target for cancer research and understanding genetic diseases.
By using the MSH4 Polyclonal Antibody, researchers can investigate the expression levels and localization of MSH4 in various cell types, providing valuable insights into its function and potential implications in disease processes. This antibody is a valuable tool for studies in genetics, cell biology, and cancer research, offering a deepened understanding of MSH4's role in maintaining genomic integrity.
Product Name:
MSH4 Rabbit Polyclonal Antibody
SKU:
CAB8556
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 697-936 of human MSH4 (NP_002431.2).
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
Purification Method:
Affinity purification
Gene ID:
4438
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MSH4 antibody (CAB8556) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
