MSH3 Rabbit Polyclonal Antibody (CAB5681)
- SKU:
- CAB5681
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MSH3 Rabbit Polyclonal Antibody |
SKU: | CAB5681 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 617-761 of human MSH3 (NP_004696.2). |
Sequence: | FNTS EEHH ADMY RSDL PNPD TLSA ELHC WRIK WKHR GKDI ELPS TIYE ALHL PDIK FFPN VYAL LKVL CILP VMKV ENER YENG RKRL KAYL RNTL TDQR SSNL ALLN INFD IKHD LDLM VDTY IKLY TSKS ELPT DNSE TVEN T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DUP; FAP4; MRP1; MSH3 |
Positive Sample: | SW620 |
Conjugate: | Unconjugated |
Cellular Localization: | nucleoplasm, nucleus |
Calculated MW: | 127kDa |
Observed MW: | 127kDa |
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.
Purification Method: | Affinity purification |
Gene ID: | 4437 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |