The MSH3 Polyclonal Antibody (CAB5681) is a valuable tool for researchers studying MSH3, a crucial protein involved in DNA mismatch repair. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the MSH3 protein, this antibody enables researchers to detect and analyze MSH3 expression in various cell types, making it an ideal choice for studies focusing on DNA repair mechanisms and genomic stability.MSH3 plays a vital role in the maintenance of genomic integrity by recognizing and repairing DNA mismatches during replication. Mutations in the MSH3 gene have been linked to various hereditary cancer syndromes and microsatellite instability, highlighting the importance of studying this protein in the context of cancer research and genetic diseases.
By understanding the functions of MSH3, researchers can uncover potential therapeutic targets for improving cancer treatment and diagnosis.Overall, the MSH3 Polyclonal Antibody (CAB5681) offers a reliable tool for investigating the role of MSH3 in DNA repair processes and its implications for disease development. Its specificity and sensitivity make it a valuable asset for researchers aiming to unravel the complexities of DNA maintenance and promote advancements in precision medicine.
Product Name:
MSH3 Rabbit Polyclonal Antibody
SKU:
CAB5681
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 617-761 of human MSH3 (NP_004696.2).
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.
Purification Method:
Affinity purification
Gene ID:
4437
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of SW620 cells, using MSH3 Rabbit pAb (CAB5681) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
