The MSH2 Rabbit Monoclonal Antibody (CAB8740) is a valuable tool for research involving MSH2, a critical protein involved in DNA mismatch repair and maintenance of genomic stability. This antibody, produced and validated for specificity in rabbit hosts, is highly reactive with human samples and is ideal for use in Western blot applications.MSH2 is a key component of the DNA mismatch repair system, responsible for recognizing and repairing errors in DNA replication. Mutations in MSH2 are associated with hereditary nonpolyposis colorectal cancer (HNPCC) and other forms of cancer, making it a crucial target for research in cancer biology and genetics.
By specifically binding to MSH2, this monoclonal antibody enables the accurate detection and analysis of MSH2 protein levels in a variety of cell types. Its reliability and sensitivity make it an essential tool for studies investigating the role of MSH2 in cancer development, progression, and potential therapeutic interventions.
Product Name:
MSH2 Rabbit Monoclonal Antibody
SKU:
CAB8740
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MSH2 (P43246).
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4436
Clone Number:
ARC1285
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using MSH2 Rabbit mAb (CAB8740) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
