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MSH2 Rabbit Monoclonal Antibody (CAB8740)

SKU:
CAB8740
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MSH2 Rabbit Monoclonal Antibody
SKU:CAB8740
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MSH2 (P43246).
Sequence:MAVQ PKET LQLE SAAE VGFV RFFQ GMPE KPTT TVRL FDRG DFYT AHGE DALL AARE VFKT QGVI KYMG PAGA KNLQ SVVL SKMN FESF VKDL LLVR QYRV
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:FCC1; COCA1; HNPCC; LCFS2; MSH-2; hMSH2; HNPCC1; LYNCH1; MMRCS2; MSH2
Positive Sample:HeLa,293T,A549,NIH/3T3,C6,Mouse testis
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:105kDa
Observed MW:105kDa

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:4436
Clone Number:ARC1285
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using MSH2 Rabbit mAb (CAB8740) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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