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MSH2 Polyclonal Antibody (CAB21739)

SKU:
CAB21739
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$167 - $635
Frequently bought together:

Description

MSH2 Polyclonal Antibody (CAB21739)

The MSH2 Polyclonal Antibody (CAB21739) is a valuable tool for researchers studying MSH2, a key protein involved in DNA repair and maintenance. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the MSH2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology, genetics, and cancer research.

MSH2 is a crucial component of the DNA mismatch repair system, which helps to correct errors that occur during DNA replication. Mutations in MSH2 have been linked to hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, highlighting the importance of studying this protein in cancer biology. Understanding the function and regulation of MSH2 is essential for developing targeted therapies and diagnostic tools for cancer and other genetic disorders.

Product Name:MSH2 Polyclonal Antibody
Product Code:CAB21739
Reactivity:Human, Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa, OVCAR3, NIH/3T3
Cellular Location:Nucleus

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-583 of human MSH2 (NP_000242.1).
Sequence:LNKCK TPQGQ RLVNQ WIKQP LMDKN RIEER LNLVE AFVED AELRQ TLQED LLRRF PDLNR LAKKF QRQAA NLQDC YRLYQ GINQL PNVIQ ALEKH EGKHQ KLLLA VFVTP LTDLR SDFSK FQEMI ETTLD MDQVE NHEFL VKPSF DPNLS ELREI MNDLE KKMQS TLISA ARDLG LDPGK QIKLD SSAQF GYYFR VTCKE EKVLR NNKNF STVDI QKNGV KFTNS KLTSL NEEYT KNKTE YEEAQ DAIVK EIVN
Synonyms:FCC1, COCA1, HNPCC, LCFS2, MSH-2, hMSH2, HNPCC1, LYNCH1, MMRCS2
Calculated MW:105kDa
Observed MW:105kDa

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