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MSH2 Polyclonal Antibody (CAB21494)

SKU:
CAB21494
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
IP
€139 - €529
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MSH2 Polyclonal Antibody
SKU:CAB21494
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MSH2 (NP_000242.1).
Sequence:MAVQ PKET LQLE SAAE VGFV RFFQ GMPE KPTT TVRL FDRG DFYT AHGE DALL AARE VFKT QGVI KYMG PAGA KNLQ SVVL SKMN FESF VKDL LLVR QYRV EVYK NRAG NKAS KEND WYLA YKAS PGNL SQFE DILF GNND MSAS IGVV GVKM SAVD GQRQ VGVG YVDS IQRK LGLC EFPD NDQF SNLE ALLI QIGP KECV LPGG ETAG DMGK LRQI IQRG GILI TERK KADF STKD IYQD LNRL LKGK KGEQ MNSA VLPE MENQ VAVS SLSA VIKF LELL SDDS NFGQ FELT TFDF SQYM
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:FCC1; COCA1; HNPCC; LCFS2; MSH-2; hMSH2; HNPCC1; LYNCH1; MMRCS2; H2
Positive Sample:HeLa,A-549
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:105kDa
Observed MW:105kDa

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:4436
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from A-549 cells, using [KO Validated] MSH2 Rabbit pAb (CAB21494) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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