The MSH2 Polyclonal Antibody (CAB1121) is a valuable tool for researchers studying MSH2, a key protein involved in DNA mismatch repair. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot and immunohistochemistry applications. By binding to the MSH2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in genetics and cancer research.MSH2 is a critical component of the DNA mismatch repair system, which plays a crucial role in maintaining genomic integrity and preventing mutations that can lead to cancer.
Mutations in MSH2 are linked to Lynch syndrome, a hereditary cancer syndrome. Understanding the function of MSH2 is essential for elucidating the mechanisms of tumorigenesis and developing targeted therapies for cancer treatment.This MSH2 Polyclonal Antibody is a reliable tool for researchers aiming to explore the complex role of MSH2 in DNA repair and cancer development. Its high specificity and sensitivity make it a valuable asset for investigations into genetic disorders and oncology.
Product Name:
MSH2 Rabbit Polyclonal Antibody
SKU:
CAB1121
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MSH2 (NP_000242.1).
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4436
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MSH2 Rabbit pAb (CAB1121) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
