The MS4A6A Antibody (PAC048750) is a polyclonal antibody designed for research involving the MS4A6A protein, a cell surface molecule implicated in immune regulation. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blotting. By binding specifically to the MS4A6A protein, this antibody enables the detection and analysis of MS4A6A in different cell types, making it ideal for studies in immunology and cancer research.
MS4A6A, also known as a member of the membrane-spanning 4A family, plays a crucial role in immune response modulation by regulating inflammation and inhibiting allergic reactions. Its significance in immune homeostasis makes it a promising target for research into diseases like cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of MS4A6A is essential for the development of therapies that can modulate immune function in these disease contexts.
Antibody Name:
MS4A6A Antibody (PACO48750)
Antibody SKU:
PACO48750
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Membrane-spanning 4-domains subfamily A member 6A protein (1-36AA)
Immunofluorescent analysis of HepG2 cells using PACO48750 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May be involved in signal transduction as a component of a multimeric receptor complex.
Synonyms:
Membrane-spanning 4-domains subfamily A member 6A (CD20 antigen-like 3) (Four-span transmembrane protein 3), MS4A6A, 4SPAN3 CD20L3 MS4A6
UniProt Protein Function:
MS4A6A: May be involved in signal transduction as a component of a multimeric receptor complex. Belongs to the MS4A family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Cell surface; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: integral to membrane
NCBI Summary:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]
