MS4A2 Rabbit Polyclonal Antibody (CAB8543)
- SKU:
- CAB8543
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | MS4A2 Rabbit Polyclonal Antibody |
SKU: | CAB8543 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MS4A2 (NP_000130.1). |
Sequence: | MDTE SNRR ANLA LPQE PSSV PAFE VLEI SPQE VSSG RLLK SASS PPLH TWLT VLKK EQEF LGVT QILT AMIC LCFG TVVC SVLD ISHI EGDI FSSF KAGY |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | APY; IGEL; IGER; ATOPY; FCERI; IGHER; FCER1B; MS4A2 |
Positive Sample: | HL-60,Raji |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Multi-pass membrane protein. |
Calculated MW: | 27kDa |
Observed MW: | 27kDa |
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
Purification Method: | Affinity purification |
Gene ID: | 2206 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |