Ms4a1 Antibody (PACO28394)
- SKU:
- PACO28394
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Ms4a1 Antibody (PACO28394)
The MS4A1 Monoclonal Antibody (PAC028394) is a valuable tool for researchers studying MS4A1, a cell surface protein involved in immune regulation and signaling. This antibody, produced in mice, is highly specific for human samples and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.MS4A1, also known as CD20, is a B-cell marker commonly used in the diagnosis and treatment of B-cell lymphomas and leukemias. It plays a crucial role in B-cell activation and differentiation, making it an important target for research in immunology and hematology.
The MS4A1 Monoclonal Antibody allows for precise detection and analysis of MS4A1 expression in different cell types, aiding in the study of B-cell biology and disease progression.With its high specificity and sensitivity, the MS4A1 Monoclonal Antibody is an essential tool for researchers seeking to unravel the complexities of B-cell function and explore new therapeutic strategies for B-cell-related disorders. Its ability to accurately detect MS4A1 expression makes it an invaluable asset in the fields of oncology, immunology, and drug development.
| Antibody Name: | Ms4a1 Antibody (PACO28394) |
| Antibody SKU: | PACO28394 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse B-lymphocyte antigen CD20 protein (111-291AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Ms4a1 antibody at 4µg/ml Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: 293T whole cell lysate Lane 4: HL60 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 32 kDa Observed band size: 32 kDa . |
| Background: | This protein may be involved in the regulation of B-cell activation and proliferation. |
| Synonyms: | B-lymphocyte antigen CD20 (B-cell differentiation antigen Ly-44) (Lymphocyte antigen 44) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20), Ms4a1, Cd20 Ly-44 Ms4a2 |
| UniProt Protein Function: | MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 19 A|19 8.19 cMCellular Component: external side of plasma membrane; extracellular exosome; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; plasma membraneMolecular Function: epidermal growth factor receptor binding; protein bindingBiological Process: B cell activation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P19437 |
| NCBI GenInfo Identifier: | 6671710 |
| NCBI Gene ID: | 12482 |
| NCBI Accession: | NP_031667.1 |
| UniProt Secondary Accession: | P19437 |
| UniProt Related Accession: | P19437 |
| Molecular Weight: | 31,958 Da |
| NCBI Full Name: | B-lymphocyte antigen CD20 |
| NCBI Synonym Full Names: | membrane-spanning 4-domains, subfamily A, member 1 |
| NCBI Official Symbol: | Ms4a1Â Â |
| NCBI Official Synonym Symbols: | Cd20; Ly-44; Ms4a2; AA960661Â Â |
| NCBI Protein Information: | B-lymphocyte antigen CD20 |
| UniProt Protein Name: | B-lymphocyte antigen CD20 |
| UniProt Synonym Protein Names: | B-cell differentiation antigen Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20 |
| Protein Family: | CD209 antigen |
| UniProt Gene Name: | Ms4a1Â Â |
| UniProt Entry Name: |
Related Products
MS4A14 Monoclonal Antibody (CAB20965)
Human MS4A1 (B-lymphocyte antigen CD20) ELISA Kit (HUFI05064)
Human Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) ELISA Kit (HUDL01906)
