The MRPS21 Polyclonal Antibody (PAC010605) is a valuable tool for researchers studying the mitochondrial ribosomal protein S21 (MRPS21), a key player in protein synthesis within mitochondria. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the MRPS21 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and mitochondrial function research.MRPS21 is essential for the assembly of the mitochondrial ribosome and plays a critical role in the translation of mitochondrial-encoded proteins.
Dysregulation of MRPS21 has been implicated in various diseases, including mitochondrial disorders and cancers. By studying the function and regulation of MRPS21, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention. The MRPS21 Polyclonal Antibody is a valuable tool for advancing our understanding of mitochondrial biology and its implications in human health.
mitochondrial ribosomal protein S21;MRPS21;MDS016;MRP-S21;RPMS21 ;
UniProt Protein Function:
MRPS21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 1q21Cellular Component: mitochondrial inner membrane; mitochondrial small ribosomal subunitMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis; translation
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]
