The MRPS21 Polyclonal Antibody (PACO01106) is a valuable tool for researchers studying mitochondrial ribosomal protein S21 (MRPS21) and its role in mitochondrial function. This antibody, produced in rabbits, shows high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to MRPS21, this antibody enables the detection and analysis of this key protein in various cell types, making it a versatile option for studies in the fields of cell biology and mitochondrial research.MRPS21 is a crucial component of the mitochondrial ribosome, playing a pivotal role in protein synthesis within the mitochondria. Dysfunction in mitochondrial ribosomal proteins like MRPS21 has been associated with various diseases, including mitochondrial disorders and cancer.
Thus, understanding the function and regulation of MRPS21 is essential for uncovering potential therapeutic targets and advancing our knowledge of mitochondrial biology.Overall, the MRPS21 Polyclonal Antibody (PACO01106) offers researchers a reliable tool for investigating the intricate roles of MRPS21 in mitochondrial function and disease pathogenesis. Its specificity and sensitivity make it an excellent choice for studies aiming to elucidate the molecular mechanisms underlying mitochondrial protein synthesis.
Antibody Name:
MRPS21 Antibody
Antibody SKU:
PACO01106
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat, Monkey
Immunogen:
synthesized peptide derived from the Internal region of human MRP-S21.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPS21; RPMS21; MDS016; 28S ribosomal protein S21; mitochondrial; MRP-S21; S21mt
UniProt Protein Function:
MRPS21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 1q21Cellular Component: mitochondrial inner membrane; mitochondrial small ribosomal subunitMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis; translation
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]
