The MRPS18B Polyclonal Antibody (CAB12085) is a valuable tool for researchers studying the mitochondrial ribosomal protein S18B (MRPS18B). This antibody, produced in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By binding to MRPS18B, this antibody facilitates the detection and analysis of the protein in various cell types, making it ideal for studies in mitochondrial biology and related fields.MRPS18B is a component of the small subunit of the mitochondrial ribosome and plays a crucial role in protein synthesis within mitochondria. Dysregulation of MRPS18B has been linked to various diseases, including cancer and neurodegenerative disorders.
Research on MRPS18B is essential for understanding mitochondrial function and dysfunction, as well as for developing targeted therapies for diseases associated with mitochondrial defects.In conclusion, the MRPS18B Polyclonal Antibody is a valuable research tool for studying MRPS18B and its role in mitochondrial biology and disease. Its high reactivity and specificity make it a reliable choice for researchers looking to advance their understanding of mitochondrial function and its implications for human health.
Product Name:
MRPS18B Rabbit Polyclonal Antibody
SKU:
CAB12085
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-258 of human MRPS18B (NP_054765.1).
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.
Purification Method:
Affinity purification
Gene ID:
28973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MRPS18B Rabbit pAb (CAB12085) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
