| Background: | mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, mitochondrial translational elongation, mitochondrial translational initiation, mitochondrial translational termination, organelle organization, translation |
| Synonyms: | 39S ribosomal protein S18a, mitochondrial (MRP-S18-a) (Mrps18a) (S18mt-a) (39S ribosomal protein S18-3, mitochondrial) (MRP-S18-3) (Mitochondrial large ribosomal subunit protein bS18a) (Mitochondrial large ribosomal subunit protein mL66), MRPS18A |
| UniProt Protein Function: | MiscellaneousThere are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b) binds to a novel location of the 28S small subunit, and mL66 (bS18a, this protein) binds to the 39S large subunit. |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010] |
| UniProt Code: | Q9NVS2 |
| NCBI GenInfo Identifier: | 301069365 |
| NCBI Gene ID: | 55168 |
| NCBI Accession: | NP_001180272.1 |
| UniProt Secondary Accession: | Q9NVS2,Q5QPA4, A6XND3 |
| UniProt Related Accession: | Q9NVS2 |
| Molecular Weight: | 14,030 Da |
| NCBI Full Name: | 39S ribosomal protein S18a, mitochondrial isoform 2 |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein S18A |
| NCBI Official Symbol: | MRPS18AÂ Â |
| NCBI Official Synonym Symbols: | S18bmt; MRPS18-3; HumanS18b; MRP-S18-3Â Â |
| NCBI Protein Information: | 39S ribosomal protein S18a, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein S18a, mitochondrial |
| UniProt Synonym Protein Names: | 39S ribosomal protein S18-3, mitochondrial; MRP-S18-3; Mitochondrial large ribosomal subunit protein bS18a |
| Protein Family: | 28S ribosomal protein |
| UniProt Gene Name: | MRPS18AÂ Â |
| UniProt Entry Name: | |
