The MRPS18A Polyclonal Antibody (PAC010602) is a valuable tool for research involving the mitochondrial ribosomal protein S18A (MRPS18A). This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the MRPS18A protein, researchers are able to detect and analyze this important mitochondrial ribosomal protein in various cell types.MRPS18A is a key component of the mitochondrial ribosome, involved in the translation of proteins within the mitochondria. This protein plays a crucial role in maintaining mitochondrial function and cellular metabolism, making it a vital target for studies in mitochondrial biology and metabolic diseases.
Understanding the function and regulation of MRPS18A can provide insights into diseases such as metabolic disorders, neurodegenerative conditions, and mitochondrial dysfunction-related disorders.Overall, the MRPS18A Polyclonal Antibody is a valuable tool for researchers studying mitochondrial ribosomal proteins and their role in cellular metabolism and disease. Its high reactivity and specificity make it ideal for experiments aimed at understanding the intricate workings of the mitochondria and their impact on human health.
mitochondrial ribosomal protein S18A;MRPS18A;FLJ10548;HumanS18b;MRP-S18-3;MRPS18-3;S18bmt ;
UniProt Protein Function:
MiscellaneousThere are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b) binds to a novel location of the 28S small subunit, and mL66 (bS18a, this protein) binds to the 39S large subunit.
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
