The MRPS11 Polyclonal Antibody (PAC010597) is a valuable tool for researchers studying the mitochondrial ribosomal protein S11 (MRPS11) and its role in mitochondrial function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.MRPS11 is a component of the mitochondrial ribosome and is essential for protein synthesis within the mitochondria. Dysregulation of MRPS11 has been associated with mitochondrial dysfunction, which can lead to a variety of diseases including neurodegenerative disorders and metabolic conditions.
By targeting MRPS11 with this antibody, researchers can investigate its involvement in these diseases and potentially uncover new treatment strategies.Overall, the MRPS11 Polyclonal Antibody is a reliable tool for studies focusing on mitochondrial biology and its implications in health and disease. Its specificity and sensitivity make it an ideal choice for researchers looking to further understand the role of MRPS11 in cellular function.
mitochondrial ribosomal protein S11;MRPS11;FLJ22512;FLJ23406;HCC-2 ;
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NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
