The MRPS10 Polyclonal Antibody (PAC028370) is a valuable tool for researchers investigating the MRPS10 protein, a component of the mitochondrial ribosome involved in protein synthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the MRPS10 protein, this antibody enables the detection and analysis of MRPS10 in various cell types, making it an ideal choice for studies in molecular biology and mitochondrial research.
MRPS10, also known as mitochondrial ribosomal protein S10, is essential for the proper functioning of the mitochondrial ribosome and plays a crucial role in mitochondrial protein synthesis. Dysregulation of MRPS10 has been associated with various mitochondrial disorders and diseases, highlighting the importance of studying its function. Investigating the role of MRPS10 can provide valuable insights into mitochondrial biology and potential therapeutic targets for mitochondrial-related conditions.
Antibody Name:
MRPS10 Antibody (PACO28370)
Antibody SKU:
PACO28370
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human 28S ribosomal protein S10, mitochondrial protein (1-201AA)
Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO28370 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO28370 at dilution of 1:100.
Background:
mitochondrial inner membrane, mitochondrion, mitochondrial translation, mitochondrial translational elongation, mitochondrial translational initiation, mitochondrial translational termination, mitophagy in response to mitochondrial depolarization, organelle organization, positive regulation of defense response to virus by host, xenophagy
Synonyms:
28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt) (Mitochondrial small ribosomal subunit protein uS10m), MRPS10
UniProt Protein Function:
MRPS10: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]Protein type: MitochondrialChromosomal Location of Human Ortholog: 6p21.1Cellular Component: mitochondrial inner membrane; mitochondrionBiological Process: positive regulation of defense response to virus by host
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]