The MRPL53 Antibody (PAC039818) is a polyclonal antibody specifically targeted towards the MRPL53 protein, which is a mitochondrial ribosomal protein involved in protein synthesis within the mitochondria. This antibody is produced in rabbits and is highly reactive with human samples, making it a valuable tool for researchers studying mitochondrial function and protein synthesis.Validated for use in Western blot applications, the MRPL53 Antibody binds specifically to the MRPL53 protein, enabling accurate detection and analysis in various cell types. Its specificity and sensitivity make it ideal for studies in molecular biology, biochemistry, and mitochondrial research.The MRPL53 protein is essential for the proper functioning of the mitochondria and is implicated in various cellular processes, including energy production and metabolism.
Dysregulation of MRPL53 has been associated with mitochondrial dysfunction and is linked to certain diseases, making it an important target for research in areas such as cancer, neurodegenerative disorders, and metabolic diseases.By utilizing the MRPL53 Antibody, researchers can gain valuable insights into the role of MRPL53 in mitochondrial function and explore its potential as a therapeutic target for diseases related to mitochondrial dysfunction. This antibody provides a reliable tool for investigating the molecular mechanisms underlying mitochondrial protein synthesis and its implications for cellular health and disease.
Antibody Name:
MRPL53 Antibody (PACO39818)
Antibody SKU:
PACO39818
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human 39S ribosomal protein L53, mitochondrial protein (8-113AA)
Immunohistochemistry of paraffin-embedded human skin tissue using PACO39818 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39818 at dilution of 1:100.
Synonyms:
39S ribosomal protein L53, mitochondrial (L53mt) (MRP-L53) (Mitochondrial large ribosomal subunit protein mL53), MRPL53
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]
