The MRPL52 Polyclonal Antibody (PAC010594) is a valuable tool for researchers studying the MRPL52 protein, a key component of the mitochondrial ribosome involved in protein synthesis within the mitochondria. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.MRPL52 is essential for the proper functioning of the mitochondrial ribosome and is crucial for the production of proteins necessary for mitochondrial activity. Dysregulation of MRPL52 has been associated with mitochondrial dysfunction, which can lead to various disease states, including metabolic disorders and neurodegenerative diseases.
By utilizing the MRPL52 Polyclonal Antibody, researchers can investigate the role of MRPL52 in mitochondrial protein synthesis and its impact on overall mitochondrial function. This antibody enables the detection and analysis of MRPL52 in various cell types, providing valuable insights for studies in mitochondrial biology, metabolic disorders, and other related research areas.
MRPL52: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.Protein type: MitochondrialChromosomal Location of Human Ortholog: 14q11.2Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosomeBiological Process: translation; mitochondrial translation; organelle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
