The MRPL52 Polyclonal Antibody (PACO3420) is a valuable tool for researchers studying the MRPL52 protein, a key player in mitochondrial ribosome assembly. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications, allowing for the detection and analysis of MRPL52 in various cell types.MRPL52 is a vital component in the biogenesis of the mitochondrial ribosome, which is responsible for synthesizing proteins within the mitochondria. Dysregulation of MRPL52 has been linked to various mitochondrial disorders, making it a target of interest in research on mitochondrial function and dysfunction.
By studying MRPL52, researchers can gain insight into the mechanisms governing mitochondrial protein synthesis and potentially uncover new therapeutic targets for mitochondrial diseases.Overall, the MRPL52 Polyclonal Antibody is a reliable tool for investigating the role of MRPL52 in mitochondrial ribosome assembly and function, with implications for understanding mitochondrial biology and developing treatments for mitochondrial disorders.
Antibody Name:
MRPL52 Antibody
Antibody SKU:
PACO03420
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human MRP-L52.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL52; 39S ribosomal protein L52; mitochondrial; L52mt; MRP-L52
UniProt Protein Function:
MRPL52: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.Protein type: MitochondrialChromosomal Location of Human Ortholog: 14q11.2Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosomeBiological Process: translation; mitochondrial translation; organelle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
