The MRPL49 Polyclonal Antibody (PACO05283) is a valuable tool for researchers studying mitochondrial ribosomal protein L49 (MRPL49), a key component of the mitochondrial ribosome involved in protein synthesis within the mitochondria. This antibody, derived from rabbits, is highly specific to human MRPL49 and has been validated for use in Western blot applications.MRPL49 is essential for the proper functioning of the mitochondrial ribosome and plays a crucial role in mitochondrial protein synthesis. Dysregulation of MRPL49 is associated with mitochondrial dysfunction and has been implicated in various diseases, including neurodegenerative disorders and cancer.
Therefore, studying the expression and activity of MRPL49 using this antibody can provide valuable insights into mitochondrial function and its role in disease pathology.This antibody allows for the detection and analysis of MRPL49 in various cell types, making it a versatile tool for researchers in the fields of molecular biology, biochemistry, and cell biology. By understanding the function of MRPL49, researchers can uncover new therapeutic targets and develop strategies to modulate mitochondrial protein synthesis for potential disease interventions.
Antibody Name:
MRPL49 Antibody (PACO05283)
Antibody SKU:
PACO05283
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human MRP-L49.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL49; C11orf4; NOF1; OK/SW-cl.67; 39S ribosomal protein L49; mitochondrial; L49mt; MRP-L49; Neighbor of FAU; NOF; Protein NOF1
UniProt Protein Function:
MRPL49: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]Protein type: Ribosomal; Translation; MitochondrialChromosomal Location of Human Ortholog: 11q13Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrial ribosomeMolecular Function: protein binding; structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]
