The MRPL47 Polyclonal Antibody (PAC004796) is a valuable tool for researchers studying MRPL47, a protein involved in mitochondrial ribosomal biogenesis. This antibody, raised in rabbits, is highly specific to human MRPL47 and is validated for use in Western blot applications. By binding to the MRPL47 protein, researchers can easily detect and analyze its expression in various cell types, making it an ideal choice for studies in molecular biology and mitochondrial research.MRPL47, a subunit of the mitochondrial ribosome, plays a crucial role in protein synthesis within the mitochondria. Dysregulation of MRPL47 has been linked to mitochondrial dysfunction and various diseases, including cancer and neurodegenerative disorders.
Understanding the function of MRPL47 is essential for unraveling the complexities of mitochondrial biology and developing targeted therapies for mitochondrial-related diseases.Overall, the MRPL47 Polyclonal Antibody (PAC004796) offers researchers a powerful tool for investigating the role of MRPL47 in mitochondrial ribosomal biogenesis and its implications in disease pathogenesis. Its high specificity and sensitivity make it an indispensable asset for advancing research in the fields of cell biology and disease mechanisms.
Antibody Name:
MRPL47 Antibody
Antibody SKU:
PACO04796
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human MRP-L47.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL47; NCM1; CGI-204; 39S ribosomal protein L47; mitochondrial; L47mt; MRP-L47; Nasopharyngeal carcinoma metastasis-related protein 1
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]
