The MRPL46 Polyclonal Antibody (CAB15428) is a valuable tool for researchers studying mitochondrial ribosomal protein L46 (MRPL46) and its role in protein synthesis within the mitochondria. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By targeting the MRPL46 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies focused on mitochondrial function, cellular metabolism, and diseases associated with mitochondrial dysfunction.MRPL46 is a key component of the mitochondrial ribosome, which is responsible for synthesizing proteins essential for mitochondrial function. Dysregulation of MRPL46 expression or function has been linked to various human diseases, including mitochondrial disorders, cancer, and metabolic disorders.
By investigating the role of MRPL46 in these diseases, researchers can gain valuable insights into pathogenic mechanisms and potentially identify new therapeutic targets for intervention.Overall, the MRPL46 Polyclonal Antibody (CAB15428) offers researchers a reliable tool for exploring the complex role of MRPL46 in mitochondrial protein synthesis and its impact on cellular health and disease. Its specificity and sensitivity make it a valuable asset for studies aiming to uncover the molecular mechanisms underlying mitochondrial-related disorders and develop innovative treatments targeting mitochondrial dysfunction.
Product Name:
MRPL46 Rabbit Polyclonal Antibody
SKU:
CAB15428
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-279 of human MRPL46 (NP_071446.2).
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
Purification Method:
Affinity purification
Gene ID:
26589
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MRPL46 Rabbit pAb (CAB15428) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
