The MRPL40 Polyclonal Antibody (CAB18191) is a valuable tool for researchers studying MRPL40, a protein involved in mitochondrial translation and protein synthesis. This rabbit-derived antibody is highly specific and reacts with human samples, making it suitable for various research applications, including Western blot analysis.MRPL40 is a key component of the mitochondrial ribosome complex and plays a crucial role in protein synthesis within the mitochondria. Dysregulation of MRPL40 has been linked to mitochondrial dysfunction and a variety of human diseases, making it an important target for further research. By using the MRPL40 Polyclonal Antibody, researchers can accurately detect and analyze MRPL40 levels in different cell types, aiding in the understanding of its function in health and disease.
The MRPL40 Polyclonal Antibody is a reliable tool for investigating the role of MRPL40 in mitochondrial biology, metabolism, and disease pathology. Its high specificity and sensitivity make it an essential reagent for studies focusing on mitochondrial function, protein synthesis, and related pathways. Gain valuable insights into the molecular mechanisms underlying mitochondrial disorders and develop potential therapeutic strategies with the use of the MRPL40 Polyclonal Antibody.
Product Name:
MRPL40 Rabbit Polyclonal Antibody
SKU:
CAB18191
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 45-206 of human MRPL40 (NP_003767.2).
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.
Purification Method:
Affinity purification
Gene ID:
64976
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MRPL40 Rabbit pAb (CAB18191) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
