The MRPL36 Antibody (PAC042010) is a vital tool for researchers studying mitochondrial ribosomal protein L36 (MRPL36), a crucial component involved in protein synthesis within the mitochondria. This polyclonal antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it an excellent choice for Western blot experiments. By targeting the MRPL36 protein, this antibody enables accurate detection and analysis in a variety of cell types, allowing for detailed investigations in the fields of molecular biology and mitochondrial research.
MRPL36 is a key player in mitochondrial translation, responsible for synthesizing essential proteins needed for proper mitochondrial function. Dysregulation of MRPL36 has been linked to various mitochondrial disorders and metabolic diseases, highlighting its potential as a therapeutic target for the treatment of these conditions. By understanding the role of MRPL36 in cellular processes, researchers can gain valuable insights into the mechanisms underlying these diseases and develop targeted interventions to address them effectively.
Antibody Name:
MRPL36 Antibody (PACO42010)
Antibody SKU:
PACO42010
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human 39S ribosomal protein L36, mitochondrial protein (2-103AA)
Component of the large subunit of the mitochondrial ribosome.
Synonyms:
39S ribosomal protein L36, mitochondrial (L36mt) (MRP-L36) (BRCA1-interacting protein 1) (Mitochondrial large ribosomal subunit protein bL36m), MRPL36, BRIP1
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]
