MRPL3 Antibody (PACO28346)
- SKU:
- PACO28346
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MRPL3 Antibody (PACO28346)
The MRPL3 Antibody (PAC028346) is a vital tool for researchers studying mitochondrial ribosomal protein L3 (MRPL3), a key component of the mitochondrial ribosome. This polyclonal antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to MRPL3, researchers can effectively detect and analyze this important protein in a variety of cell types, making it ideal for studies in mitochondrial biology and related research fields.MRPL3 is essential for mitochondrial protein synthesis, playing a critical role in maintaining mitochondrial function and overall cellular metabolism.
Dysregulation of MRPL3 has been linked to various diseases, including metabolic disorders, neurodegenerative conditions, and cancer. By investigating the function and regulation of MRPL3, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.The MRPL3 Antibody offers researchers a powerful tool for investigating the role of MRPL3 in cellular physiology and disease pathology. Its high specificity and sensitivity make it an invaluable asset for studies aiming to unravel the complex functions of mitochondrial proteins and their implications for human health.
| Antibody Name: | MRPL3 Antibody (PACO28346) |
| Antibody SKU: | PACO28346 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human 39S ribosomal protein L3, mitochondrial protein (201-348AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: MRPL3 antibody at 6µg/ml Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 39 kDa Observed band size: 39 kDa . |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO28346 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO28346 at dilution of 1:100. |
| Background: | mitochondrial inner membrane, mitochondrial large ribosomal subunit, poly(A) RNA binding, RNA binding, mitochondrial translation, mitochondrial translational elongation, mitochondrial translational initiation, mitochondrial translational termination, organelle organization, translation |
| Synonyms: | 39S ribosomal protein L3, mitochondrial (L3mt) (MRP-L3) (Mitochondrial large ribosomal subunit protein uL3m), MRPL3, MRL3 RPML3 |
| UniProt Protein Function: | MRPL3: Defects in MRPL3 are the cause of combined oxidative phosphorylation deficiency type 9 (COXPD9). A mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases. Belongs to the ribosomal protein L3P family.Protein type: Mitochondrial; Ribosomal; Translation; RNA-bindingChromosomal Location of Human Ortholog: 3q21-q23Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosome; RNA bindingBiological Process: mitochondrial translation; translation; organelle organization and biogenesisDisease: Combined Oxidative Phosphorylation Deficiency 9 |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09001 |
| NCBI GenInfo Identifier: | 6005862 |
| NCBI Gene ID: | 11222 |
| NCBI Accession: | NP_009139.1 |
| UniProt Secondary Accession: | P09001,Q6IBT2 |
| UniProt Related Accession: | P09001 |
| Molecular Weight: | 38,633 Da |
| NCBI Full Name: | 39S ribosomal protein L3, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L3 |
| NCBI Official Symbol: | MRPL3Â Â |
| NCBI Official Synonym Symbols: | MRL3; RPML3; COXPD9Â Â |
| NCBI Protein Information: | 39S ribosomal protein L3, mitochondrial; L3mt; MRP-L3; mitochondrial 60S ribosomal protein L3 |
| UniProt Protein Name: | 39S ribosomal protein L3, mitochondrial |
| UniProt Synonym Protein Names: | |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL3Â Â |
| UniProt Entry Name: | RM03_HUMAN |
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