The MRPL23 Polyclonal Antibody (CAB16424) is a valuable tool for researchers studying MRPL23, a key protein involved in mitochondrial ribosome biogenesis. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the MRPL23 protein, this antibody allows for the detection and analysis of MRPL23 in various cell types, providing insight into its role in mitochondrial function and ribosome assembly.MRPL23 is essential for the proper functioning of the mitochondria, the powerhouse of the cell, and abnormalities in its expression or activity have been linked to various diseases, including cancer and metabolic disorders.
By studying MRPL23 using this antibody, researchers can gain a better understanding of how disruption in mitochondrial ribosome biogenesis contributes to these diseases and potentially identify novel therapeutic targets.Overall, the MRPL23 Polyclonal Antibody (CAB16424) is a valuable tool for researchers interested in unraveling the complexities of mitochondrial function and its implications for human health. Its high specificity and reactivity with human samples make it a reliable choice for studies in mitochondrial biology, cancer research, and metabolic disorders.
Product Name:
MRPL23 Rabbit Polyclonal Antibody
SKU:
CAB16424
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-153 of human MRPL23 (NP_066957.3).
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.
Purification Method:
Affinity purification
Gene ID:
6150
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MRPL23 Rabbit pAb (CAB16424) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
