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MRPL21 Antibody (PACO10579)

SKU:
PACO10579
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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MRPL21 Antibody (PACO10579)

The MRPL21 Polyclonal Antibody (PAC010579) is a valuable tool for researchers studying MRPL21, a key player in mitochondrial ribosome biogenesis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the MRPL21 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of molecular biology and cellular metabolism.MRPL21, also known as mitochondrial ribosomal protein L21, is essential for the assembly and function of mitochondrial ribosomes, which are responsible for protein synthesis within the mitochondria.

Dysregulation of MRPL21 has been linked to various diseases, including metabolic disorders and mitochondrial dysfunction. By studying the role of MRPL21 in cellular processes, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.

Antibody Name:MRPL21 Antibody (PACO10579)
Antibody SKU:PACO10579
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human MRPL21
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:mitochondrial ribosomal protein L21;MRPL21;L21mt;MGC62013;MRP-L21 ;
UniProt Protein Function:MRPL21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 11q13.3Cellular Component: mitochondrial inner membrane; ribosomeMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis
UniProt Protein Details:
NCBI Summary:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
UniProt Code:Q7Z2W9
NCBI GenInfo Identifier:31652228
NCBI Gene ID:219927
NCBI Accession:NP_852616.1
UniProt Secondary Accession:Q7Z2W9,A6NKU0, C9JPR2
UniProt Related Accession:Q7Z2W9
Molecular Weight:13,746 Da
NCBI Full Name:39S ribosomal protein L21, mitochondrial isoform a
NCBI Synonym Full Names:mitochondrial ribosomal protein L21
NCBI Official Symbol:MRPL21  
NCBI Official Synonym Symbols:L21mt; MRP-L21  
NCBI Protein Information:39S ribosomal protein L21, mitochondrial
UniProt Protein Name:39S ribosomal protein L21, mitochondrial
UniProt Synonym Protein Names:
Protein Family:39S ribosomal protein
UniProt Gene Name:MRPL21  
UniProt Entry Name:RM21_HUMAN

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