UniProt Protein Function: | MRPL21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 11q13.3Cellular Component: mitochondrial inner membrane; ribosomeMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis |
UniProt Protein Details: | |
NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q7Z2W9 |
NCBI GenInfo Identifier: | 31652228 |
NCBI Gene ID: | 219927 |
NCBI Accession: | NP_852616.1 |
UniProt Secondary Accession: | Q7Z2W9,A6NKU0, C9JPR2 |
UniProt Related Accession: | Q7Z2W9 |
Molecular Weight: | 13,746 Da |
NCBI Full Name: | 39S ribosomal protein L21, mitochondrial isoform a |
NCBI Synonym Full Names: | mitochondrial ribosomal protein L21 |
NCBI Official Symbol: | MRPL21Â Â |
NCBI Official Synonym Symbols: | L21mt; MRP-L21Â Â |
NCBI Protein Information: | 39S ribosomal protein L21, mitochondrial |
UniProt Protein Name: | 39S ribosomal protein L21, mitochondrial |
UniProt Synonym Protein Names: | |
Protein Family: | 39S ribosomal protein |
UniProt Gene Name: | MRPL21Â Â |
UniProt Entry Name: | RM21_HUMAN |