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MRPL20 Antibody (PACO40510)

SKU:
PACO40510
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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MRPL20 Antibody (PACO40510)

The MRPL20 Polyclonal Antibody (PAC040510) is a valuable tool for researchers studying the mitochondrial ribosomal protein MRPL20. This antibody is raised in rabbits and has high reactivity with human samples. It has been validated for use in Western blot applications, allowing for the detection and analysis of MRPL20 in various cell types.MRPL20 is a key player in protein synthesis within the mitochondria, making it essential for cellular function. Studies have shown that abnormalities in MRPL20 expression can lead to mitochondrial dysfunction and have been linked to various diseases, including cancer and metabolic disorders.

By using the MRPL20 Polyclonal Antibody, researchers can gain insights into the role of MRPL20 in these diseases and potentially identify new therapeutic targets.Overall, the MRPL20 Polyclonal Antibody is a versatile tool for researchers in the fields of molecular biology, biochemistry, and biomedicine. Its specificity and reliability make it a valuable addition to any laboratory conducting research on mitochondrial proteins and their implications in health and disease.

Antibody Name:MRPL20 Antibody (PACO40510)
Antibody SKU:PACO40510
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human 39S ribosomal protein L20, mitochondrial protein (46-149AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human skin tissue using PACO40510 at dilution of 1:100.
Synonyms:39S ribosomal protein L20, mitochondrial (L20mt) (MRP-L20) (Mitochondrial large ribosomal subunit protein bL20m), MRPL20
UniProt Protein Function:MRPL20: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. [provided by RefSeq, Jul 2008]Protein type: MitochondrialChromosomal Location of Human Ortholog: 1p36.3-p36.2Cellular Component: mitochondrial inner membrane; mitochondrial ribosome; mitochondrionMolecular Function: protein binding; rRNA binding; structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis; ribosomal large subunit assembly and maintenance
UniProt Protein Details:
NCBI Summary:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
UniProt Code:Q9BYC9
NCBI GenInfo Identifier:26638657
NCBI Gene ID:55052
NCBI Accession:NP_060441.2
UniProt Secondary Accession:Q9BYC9,B2RE41, B7Z746
UniProt Related Accession:Q9BYC9
Molecular Weight:18,099 Da
NCBI Full Name:39S ribosomal protein L20, mitochondrial isoform 1
NCBI Synonym Full Names:mitochondrial ribosomal protein L20
NCBI Official Symbol:MRPL20  
NCBI Official Synonym Symbols:L20mt; MRP-L20  
NCBI Protein Information:39S ribosomal protein L20, mitochondrial
UniProt Protein Name:39S ribosomal protein L20, mitochondrial
UniProt Synonym Protein Names:
Protein Family:39S ribosomal protein
UniProt Gene Name:MRPL20  
UniProt Entry Name:RM20_HUMAN
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