The MRPL20 Polyclonal Antibody (PACO01095) is designed for research involving MRPL20, a mitochondrial ribosomal protein involved in the translation of mitochondrial DNA. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including Western blot and immunofluorescence. It binds specifically to the MRPL20 protein, allowing for the detection and analysis of this important mitochondrial ribosomal protein in different cell types.MRPL20 plays a crucial role in mitochondrial protein synthesis and is essential for maintaining mitochondrial function and overall cellular metabolism. Dysregulation of MRPL20 has been implicated in various diseases such as cancer, neurodegenerative disorders, and metabolic dysfunction.
Studying the function and expression of MRPL20 can provide valuable insights into the mechanisms underlying these diseases and potentially lead to the development of novel therapeutic strategies targeting mitochondrial dysfunction.Overall, the MRPL20 Polyclonal Antibody is a valuable tool for researchers interested in studying mitochondrial protein synthesis, mitochondrial dysfunction, and the role of MRPL20 in various cellular processes and diseases. Its high specificity and reactivity with human samples make it an ideal choice for immunology, cancer research, and molecular biology studies.
Antibody Name:
MRPL20 Antibody
Antibody SKU:
PACO01095
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human MRP-L20.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL20; 39S ribosomal protein L20; mitochondrial; L20mt; MRP-L20
UniProt Protein Function:
MRPL20: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. [provided by RefSeq, Jul 2008]Protein type: MitochondrialChromosomal Location of Human Ortholog: 1p36.3-p36.2Cellular Component: mitochondrial inner membrane; mitochondrial ribosome; mitochondrionMolecular Function: protein binding; rRNA binding; structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis; ribosomal large subunit assembly and maintenance
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
