The MRPL19 Antibody (PAC010577) is a highly specific and sensitive tool for research involving the MRPL19 protein, a component of the mitochondrial ribosome. This polyclonal antibody, raised against MRPL19, is suitable for use in various applications such as Western blotting and immunofluorescence. It is validated for use with human samples and offers reliable detection and analysis of MRPL19 in different cell types.MRPL19 is a key player in protein synthesis within the mitochondria, making it essential for proper cellular function and energy production. Dysregulation of MRPL19 has been linked to various diseases, including metabolic disorders and neurological conditions.
Research on MRPL19 is crucial for understanding mitochondrial biology and developing targeted therapies for related diseases.With its high specificity and sensitivity, the MRPL19 Antibody (PAC010577) is an invaluable tool for scientists studying mitochondrial ribosomes and their role in cellular health and disease. Its use in research can provide insights into the mechanisms underlying mitochondrial dysfunction and guide the development of novel therapeutic strategies.
mitochondrial ribosomal protein L19;MRPL19;KIAA0104;L19mt;MGC20675;MRP-L15;MRP-L19;MRPL15;RLX1;RPML15 ;
UniProt Protein Function:
MRPL19: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]Protein type: Translation; Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 2p11.1-q11.2Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; nuclear membrane; nucleusMolecular Function: structural constituent of ribosome
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
