The MRPL10 Polyclonal Antibody (PACO10572) is a valuable tool for researchers studying MRPL10, a mitochondrial ribosomal protein with implications in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MRPL10 protein, researchers can detect and analyze its expression in different cell types, making it ideal for investigations in molecular biology and mitochondrial function.MRPL10 is an essential component of the mitochondrial ribosome and plays a crucial role in protein synthesis within the mitochondria. Research on MRPL10 has shed light on its involvement in mitochondrial dysfunction and its association with diseases such as neurodegenerative disorders and cancer.
Understanding the function of MRPL10 is vital for unraveling the complexities of mitochondrial biology and its relevance in health and disease.Overall, the MRPL10 Polyclonal Antibody (PACO10572) serves as a valuable tool for researchers interested in exploring the role of MRPL10 in various cellular processes and disease conditions. Its specificity and reliability make it a trustworthy reagent for advancing scientific knowledge in the fields of molecular biology and mitochondrial research.
mitochondrial ribosomal protein L10;MRPL10;L10MT;MGC17973;MRP-L10;MRP-L8;MRPL8;RPML8 ;
UniProt Protein Function:
MRPL10: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]Protein type: Ribosomal; Mitochondrial; TranslationChromosomal Location of Human Ortholog: 17q21.32Cellular Component: nucleoplasm; mitochondrion; mitochondrial inner membrane; ribonucleoprotein complex; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; translation; organelle organization and biogenesis; ribosome biogenesis and assembly
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]
