| UniProt Protein Function: | MRPL10: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]Protein type: Ribosomal; Mitochondrial; TranslationChromosomal Location of Human Ortholog: 17q21.32Cellular Component: nucleoplasm; mitochondrion; mitochondrial inner membrane; ribonucleoprotein complex; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; translation; organelle organization and biogenesis; ribosome biogenesis and assembly |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q7Z7H8 |
| NCBI GenInfo Identifier: | 22547114 |
| NCBI Gene ID: | 124995 |
| NCBI Accession: | NP_660298.2 |
| UniProt Secondary Accession: | Q7Z7H8 |
| UniProt Related Accession: | Q7Z7H8 |
| Molecular Weight: | ~ 29kDa |
| NCBI Full Name: | 39S ribosomal protein L10, mitochondrial isoform a |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L10 |
| NCBI Official Symbol: | MRPL10Â Â |
| NCBI Official Synonym Symbols: | L10MT; MRPL8; RPML8; MRP-L8; MRP-L10Â Â |
| NCBI Protein Information: | 39S ribosomal protein L10, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L10, mitochondrial |
| UniProt Synonym Protein Names: | 39S ribosomal protein L8, mitochondrial |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL10Â Â |
| UniProt Entry Name: | RM10_HUMAN |
