The Mrp4/ABCC4 Monoclonal Antibody (CAB22601) is a powerful tool for researchers studying the multidrug resistance protein 4 (Mrp4), also known as ATP-binding cassette sub-family C member 4 (ABCC4). This antibody, developed using advanced monoclonal antibody technology, specifically targets the Mrp4/ABCC4 protein, allowing for precise detection and analysis in various experimental settings.Mrp4/ABCC4 is a transporter protein involved in the efflux of a wide range of molecules, including drugs and signaling molecules, from cells. Its overexpression has been linked to chemoresistance in cancer cells, making it a key player in understanding drug resistance mechanisms.
Additionally, Mrp4/ABCC4 has been implicated in various physiological processes, such as inflammatory responses and tissue homeostasis, making it a promising target for research in immunology and pharmacology.By utilizing the Mrp4/ABCC4 Monoclonal Antibody (CAB22601), researchers can gain valuable insights into the role of this transporter protein in health and disease. This antibody is validated for use in Western blot applications and is highly specific for detecting Mrp4/ABCC4 in human samples, making it an essential tool for studies aiming to elucidate the function and regulation of this important protein.
Product Name:
MRP4/ABCC4 Monoclonal Antibody
SKU:
CAB22601
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1067-1325 of human MRP4/ABCC4. (NP_005836.2).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10257
Clone Number:
ARC52223
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using [KD Validated] MRP4/ABCC4 Rabbit mAb (CAB22601) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
