The MRNIP Polyclonal Antibody (PAC036826) is a valuable tool for researchers studying the MRNIP protein, a key player in DNA repair and maintenance processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MRNIP protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in genetics, oncology, and molecular biology.MRNIP, also known as the Mre11-Rad50-Nbs1 (MRN) complex interacting protein, is involved in the activation of DNA damage response pathways and plays a crucial role in maintaining genome stability.
Dysregulation of MRNIP expression has been implicated in various diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. By studying the function of MRNIP, researchers can gain valuable insights into the mechanisms of DNA repair and identify potential targets for therapeutic intervention in disease settings.
Antibody Name:
MRNIP Antibody (PACO36826)
Antibody SKU:
PACO36826
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human MRN complex-interacting protein (1-200AA)
Western blot. All lanes: MRNIP antibody at 4µg/ml. Lane 1: Mouse kidney tissue. Lane 2: Mouse heart tissue. Lane 3: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 38, 30, 32 kDa. Observed band size: 38 kDa.
Background:
Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair.
Synonyms:
MRN complex-interacting protein (MRN-interacting protein), MRNIP, C5orf45
