The mRNA Export Factor Polyclonal Antibody (CAB6713) is a valuable tool for researchers studying mRNA export factors in cellular processes. This antibody, generated in rabbits, is highly specific and reacts with human samples in Western blot applications. By targeting the mRNA export factor protein, this antibody enables researchers to detect and analyze its expression in various cell types, providing insights into mRNA transport mechanisms.The mRNA export factor is a crucial player in the regulation of gene expression, playing a key role in the transport of mRNA from the nucleus to the cytoplasm.
Dysregulation of mRNA export factors has been implicated in various diseases, including cancer and genetic disorders. By using this antibody, researchers can gain a better understanding of how mRNA export factors function and potentially identify new therapeutic targets for disease intervention.Overall, the mRNA Export Factor Polyclonal Antibody (CAB6713) is a valuable tool for researchers interested in studying mRNA transport mechanisms and its implications in disease pathology. Its high specificity and reactivity make it a reliable resource for advancing research in this field.
Product Name:
RAE1 Rabbit Polyclonal Antibody
SKU:
CAB6713
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human RAE1 (NP_003601.1).
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8480
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RAE1 antibody (CAB6713) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
