The MRGPRX3 Polyclonal Antibody (PAC039610) is a valuable tool for research involving MRGPRX3, a G protein-coupled receptor known for its role in mediating itch and pain sensation. This antibody, produced through immunization of rabbits, is highly specific for human samples and is well-suited for use in Western blot applications. By binding to the MRGPRX3 protein, this antibody allows for the detection and analysis of MRGPRX3 expression in various cell types, making it an excellent choice for studies in neuroscience and pain research.
MRGPRX3 is a receptor involved in sensory perception, particularly in the transmission of itch and pain signals. Understanding the function and regulation of MRGPRX3 is crucial for developing strategies to alleviate symptoms associated with chronic itch and pain conditions. Research into MRGPRX3 signaling pathways could potentially lead to the development of novel therapeutics targeting this receptor for the treatment of various neurological disorders.
Antibody Name:
MRGPRX3 Antibody (PACO39610)
Antibody SKU:
PACO39610
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Mas-related G-protein coupled receptor member X3 protein (276-322AA)
Immunofluorescent analysis of HepG2 cells using PACO39610 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins.
MRGPRX3: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: 11p15.1Cellular Component: integral to plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]
