MRE11 Rabbit Polyclonal Antibody (CAB2559)
- SKU:
- CAB2559
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MRE11 Rabbit Polyclonal Antibody |
SKU: | CAB2559 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human MRE11 (NP_005582.1). |
Sequence: | MSTA DALD DENT FKIL VATD IHLG FMEK DAVR GNDT FVTL DEIL RLAQ ENEV DFIL LGGD LFHE NKPS RKTL HTCL ELLR KYCM GDRP VQFE ILSD QSVN FGFS KFPW VNYQ DGNL NISI PVFS IHGN HDDP TGAD ALCA LDIL SCAG FVNH FGRS MSVE KIDI SPVL LQKG STKI ALYG LGSI PDER LYRM FVNK KVTM LRPK EDEN SWFN LFVI HQNR SKHG STNF IPEQ FLDD FIDL VIWG HEHE CKIA PTKN EQQL FYIS QPGS SVVT SLSP GEAV KKHV GLLR IKGR KMNM HKIP LH |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | ATLD; HNGS1; MRE11A; MRE11B; MRE11 |
Positive Sample: | K-562,Neuro-2a,Mouse liver,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 81kDa |
Observed MW: | 81kDa |
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 4361 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |